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KMID : 0043320080310121597
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Archives of Pharmacal Research
2008 Volume.31 No. 12 p.1597 ~ p.1603
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Anti-allergic Activity of an Ethanol Extract from Salviae miltiorrhiza
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Chang Hyun-Wook
Yang Ju-Hye
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Abstract
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As part of an ongoing investigation aimed at the discovery of novel bioactive medicinal herbs with antiinflammatory properties, the effects of an ethanolic extract from the parts of Salviae miltiorrhiza Bunge (ESM) were evaluated using in vitro and in vivo animal model analysis. ESM inhibited cyclooxygenase- 2 (COX-2) and COX-1-dependent phases of prostaglandin D2 (PGD2) generation in bone marrowderived mast cells (BMMC) in a concentration-dependent manner with IC50 values of 3.96 μg/mL and 21.54 μg/mL, respectively. Furthermore, ESM inhibited leukotriene C4 (LTC4) production with an IC50 value of 2.6 μg/mL. These results clearly demonstrated the dual COX-2 selective/5-lipoxygenase inhibitory activity that ESM possessed. ESM strongly inhibited a degranulation reaction in a dose dependent manner within a BMMC system, with an IC50 value of 22.4 μg/mL. Additionally, ESM was tested in a rat passive cutaneous anaphylaxis (PCA) reaction assay by oral administration (25 to 100 mg/kg). ESM dose-dependently inhibited the PCA reaction, which was activated by anti-dinirophenyl (DNP) IgE. These results suggested that ESM might be beneficial in regulating various allergic reactions.
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KEYWORD
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Salviae miltiorrhiza, Allergy, Bone marrow derived mast cells, Passive cutaneous anaphylaxis (PCA) reaction
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